Beilstein J. Org. Chem.2023,19, 282–293, doi:10.3762/bjoc.19.24
inhibitor:enzyme complexes were analyzed by molecular modeling.
Keywords: glycosidase inhibitor; GolgimannosidaseII; iminosugar; inhibition; molecular modeling; Introduction
Iminosugars are analogs of monosaccharides in which the endocyclic oxygen atom is replaced with a nitrogen atom [1][2][3][4][5]. These
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Graphical Abstract
Figure 1:
Natural iminosugars (1,4-dideoxy-1,4-imino-ᴅ-mannitol (DIM) and swainsonine) and selected examples ...
Beilstein J. Org. Chem.2018,14, 2156–2162, doi:10.3762/bjoc.14.189
swainsonine, interferes with the glycosylation pathway where it specifically inhibits GH38 glycoside hydrolases [23][24]. Up to date, swainsonine is the most potent GolgimannosidaseII (GMII) inhibitor. It is known that inhibition of the biosynthesis of complex N-glycans in the Golgi apparatus influences